Read mapping is a crucial task in computational genomics. Recently, there has been a significant paradigm shift from sequence-to-sequence mapping (S2S) to sequence-to-graph mapping (S2G). The S2G mapping incurs high graph processing overheads and leads to an unnoticed shift of performance hotspots. This presents a substantial challenge to current software implementations and hardware accelerators.
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Zhang et al. (2024) studied this question.
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