Research Progress on the Mechanism of Sivelestat Sodium in Sepsis-Related Organ Dysfunction

Sepsis is a life-threatening organ dysfunction caused by the host 's dysfunctional response to infection, which seriously threatens life and health. The pathogenesis of sepsis is very complicated. Neutrophil elastase is closely related to the occurrence and development of sepsis. It promotes the migration of immune cells and induces the release of pro-inflammatory mediators by degrading extracellular matrix, thus causing organ dysfunction. Sivelestat sodium has received continuous attention in recent years due to its specific inhibition of neutrophil elastase and its possible role in sepsis-related organs through multiple pathways. This article reviews the research progress of the mechanism of sivelestat sodium in sepsis-related organ dysfunction.