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April 23, 2024BMC CancerOpen Access

Identification of BGN positive fibroblasts as a driving factor for colorectal cancer and development of its related prognostic model combined with machine learning

Shangshang Hu Qianni Xiao Rui Gao Jian Qin Junjie Nie Yuhan Chen Jinwei Lou Muzi Ding Yuqin Pan Shukui Wang

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Abstract

Numerous studies have indicated that cancer-associated fibroblasts (CAFs) play a crucial role in the progression of colorectal cancer (CRC). However, there are still many unknowns regarding the exact role of CAF subtypes in CRC.

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Cite This Study

Hu et al. (2024) studied this question.

synapsesocial.com/papers/68e6df9ab6db64358765b519 https://doi.org/10.1186/s12885-024-12251-4

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Molecular features and clinical significance of Cancer-Associated Fibroblasts in colorectal cancerReview · 2026
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3An integrated spatially defined roadmap of normal and cancer-associated colon fibroblastsOriginal Research · 2026
4Cancer‐associated fibroblasts are associated with <scp>CD8</scp> + T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi‐omics and machine learning analysisPrognostic Study · 2026
5High-resolution integrative analysis allows characterization and spatial annotation of normal and cancer-associated colon fibroblasts2025 · 3 citations

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