Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis

Robert J. Fox; Bruce Cree; de Sèze; Ralf Gold; Hans‐Peter Hartung; Douglas Jeffery; Ludwig Kappos; Xavier Montalbán; Bianca Weinstock‐Guttman; Carol M. Singh; Arman Altincatal; Nicholas Belviso; Robin L. Avila; Pei‐Ran Ho; Ray Su; Robert B. Engle; Dipen Sangurdekar; Carl de Moor; Elizabeth Fisher; Bernd C. Kieseier; Richard A. Rudick

doi:10.1212/wnl.0000000000209357

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Abstract

Serum neurofilament light chain (sNfL) levels correlate with multiple sclerosis (MS) disease activity, but the dynamics of this correlation are unknown. We evaluated the relationship between sNfL levels and radiologic MS disease activity through monthly assessments during the 24-week natalizumab treatment interruption period in RESTORE (NCT01071083).

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Fox et al. (2024) studied this question.

synapsesocial.com/papers/68e6e0a4b6db64358765c9f0 https://doi.org/10.1212/wnl.0000000000209357

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Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis

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Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis

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