RAPNO efforts in Brain Tumour Outcomes

Assessing treatment efficacy for brain tumours has evolvedsince its inception with the introduction of MacDonald’scriteria, which pioneered the utility of imaging todetermine an objective and quantifiable response totreatment. This criterion failed to distinguish pseudoresponse or progression from progression and did notaccount for non-enhancing disease therefore; the responseassessment in neuro-oncology (RANO) working group wasestablished to account for these limitations. Since, itscommencement it has worked to determine responseassessment for multiple tumours. As paediatric tumoursexhibit heterogeneous and variable-enhancingcharacteristics, the response assessment in paediatricneuro-oncology (RAPNO) working group was formed tocreate separate criteria. Six response criteria have beenpublished to date, and the article summarizes them.