A study on patients’ selection for BRCA1 and BRCA2 mutations testing by different models in Libyan women with breast cancer

Introduction The BRCA mutation spectrum of familial breast cancer in Libya remains unknown. Several genetic models developed to predict the probability of BRCA1/2 mutations have not been applied in Libya, where the NCCN criteria are used for highly penetrating breast cancer susceptibility genes. We aimed to predict BRCA1/2 mutation probability in familial breast cancer and genetic testing eligibility using BOADICEA and BRCAPRO models and NCCN criteria.