International Session 14 Otology-Clinical 4

Objective: Doxycycline(Dc)is a broad-spectrum bacteriostatic antibiotic of the tetracycline class, which also has antiinflammatory action including reduction of ECP and MMP-9, and antibiotic activity against S.aureus.The purpose of this study was to investigate the effect of Dc on postoperative outcomes in CRS patients.Methods: Of the CRS patients who underwent ESS from 2020 to 2021 December, 43 adult patients(18 patients taking Dc after ESS for average 12weeks［200mg loading dose, then 100mg daily］and 25 patients without Dc)showing eosinophilic CRS were enrolled in this study.Subjective symptoms(SNOT-22) , postoperative endoscopic scores(Lund-Kennedy score) , and olfactory outcome were compared between Dc-taking group and Dc-free group to investigate the effect of Dc on postoperative outcomes.Results: Compared to patients without Dc, there was a significant improvement in total scores of SNOT-22 in patients with Dc postoperatively(27． 3-5． 4 vs 18． 7-7． 7, P＝0． 04) .When we assessed 22 individual symptoms, statistically significant decreases were found in symptoms including post-nasal discharge and cough(all, P＜0． 05) .Additionally, patients with Dc had significantly better outcomes in postoperative endoscopic scores regarding mucosal edema, compared to those without Dc(P＝0． 03) .However, no significant differences were observed in postoperative olfactory outcomes between the two groups.Conclusions: Doxycycline may have a beneficial role for postoperative disease control status in eosinophilic CRS.