A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms: Results from ECOG-ACRIN E1Z11

Vered Stearns; Opeyemi A. Jegede; Victor T. Chang; Todd C. Skaar; Jeffrey L. Berenberg; Ranveer Nand; Atif Shafqat; Nisha L. Jacobs; William Luginbuhl; Paul Gilman; Al B. Benson; Judie R. Goodman; Gary L. Buchschacher; N. Lynn Henry; Charles L. Loprinzi; Patrick J. Flynn; Edith P. Mitchell; Michael Fisch; Joseph A. Sparano; Lynne I. Wagner

doi:10.1158/1078-0432.ccr-23-2137

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Abstract

Aromatase inhibitor (AI)-associated musculoskeletal symptoms (AIMSS) are common and frequently lead to AI discontinuation. SNPs in candidate genes have been associated with AIMSS and AI discontinuation. E1Z11 is a prospective cohort study designed to validate the association between 10 SNPs and AI discontinuation due to AIMSS.

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Stearns et al. (2024) studied this question.

synapsesocial.com/papers/68e6e65fb6db643587661888 https://doi.org/10.1158/1078-0432.ccr-23-2137

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A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms: Results from ECOG-ACRIN E1Z11

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A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms: Results from ECOG-ACRIN E1Z11

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Abstract

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Cite This Study

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