The Esthesioneuroblastoma (ENB) as a rare tumor entity in Otorhinolaryngology

Introduction The esthesioneuroblastoma (ENB) is a rare malignant tumor of neuroepithelial olfactory cells. The incidence comprises 0,4 of 1 Million in 2019. Due to its anatomic relationship it is likely to affect the skull base and orbit. The clinical appearance takes place through unspecific symptoms such as epistaxis and headache. The ENB is characterized by its local invasiveness and formation of metastasis in cervical lymph nodes, the lung or spine. Therefore a whole-body staging including a PET-CT is recommended besides obligatory CT-/MR-scan of the primary. Concerning the treatment of ENB every case needs to be evaluated individually to form a multimodal therapy concept.