RNA-binding proteins affect growth of HNSCC cell lines

Introduction RNA-binding proteins (RBPs) can affect tumor growth and metastasis through regulation of transcription of tumor-associated proteins. In that context, the polypyrimidine tract binding protein 1 (PTBP1), human antigen R (HuR, aka ELAVL1), cytoplasmic polyadenylation element binding protein 1 (CPEB1) and the RNA binding motif protein 38 (RBM38) have been associated with hypoxia-inducible factor 1 (HIF1) mRNA regulation.