Introduction The management of Oropharyngeal Squamous Cell Carcinomas (OPSCC) significantly benefits from improved stratification methods, especially considering the pivotal role of Human Papillomavirus (HPV) association in prognosticating disease course. Traditional methods, including p16 immunohistochemistry and HPV DNA detection, may not fully capture tumor heterogeneities and patient subpopulations.
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Kopp et al. (2024) studied this question.
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