Mepolizumab for individual treatment of refractory eosinophilic sialodochitis

Introduction Eosinophilic sialodochitis is a rare but emerging disease that can cause salivary gland swelling, eosinophilic-rich mucus plugs and eosinophilic infiltration of the salivary duct. Symptoms reach from itching to severe pain and recurrent salivary duct obstruction. Treatment of eosinophilic sialodochitis comprises sialogogic measures, antihistamines, leukotriene receptor antagonists, oral corticosteroids as well as surgical interventions such as sialendoscopy and corticosteroid irrigation of the salivary duct.