Combination therapy with mepolizumab and dupilumab in a patient with severe uncontrolled chronic rhinosinusitis with nasal polyps in the context of eosinophilic granulomatosis with polyangiitis

Introduction Monoclonal antibodies (biologics) are increasingly used in the treatment of severe uncontrolled forms of chronic rhinosinusitis with nasal polyps. In some patients with comorbidities, a combination therapy of biologics needs to be discussed and can be useful as an individual therapy concept.