Review demonstrates improved tumor targeting and reduced toxicity with CXCR4-targeted nanoparticles in cancer, highlighting opportunities for precision therapy.
Nanoparticle (NP) functionalization with specific ligands enhances targeted cancer therapy and imaging by promoting receptor recognition and improving cellular uptake. This review focuses on recent research exploring the interaction between cancer cell-expressed chemokine receptor 4 (CXCR4) and ligand-conjugated NPs, utilizing small molecules, peptides, and antibodies. Active NP targeting has shown improved tumor targeting and reduced toxicity, enabling precision therapy and diagnosis.
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Alcantara et al. (2024) studied this question.
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