Alkyl ammonium hydrogen sulfate immobilized on Fe3O4@SiO2 nanoparticles: a highly efficient catalyst for the multi-component preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives

In this, a three-component reaction for the preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives from N,N′ -(sulfonylbis(1,4-phenylene))bis(3-oxobutanamide), aldehydes and 1 H -tetrazol-5-amine is reported. The application of Fe 3 O 4 @SiO 2 -(PP)(HSO 4 ) 2 (A) as a catalyst afforded the desired products (a 1 –a 18 ) in high yields in DMF as solvent as well as under solvent-free conditions.