Emerging Therapies for Familial Lecithin-Cholesterol Acyltransferase Deficiency: A Role for Plasma Exchange

Familial lecithin-cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare disorder of lipid metabolism causing decreased maturation of high-density lipoprotein (HDL) particles and impaired cholesterol esterification1. Patients with FLD develop corneal opacification, haemolytic anaemia, proteinuria, and lipid abnormalities including elevated triglycerides (TG), reduced HDL cholesterol and increased unesterified cholesterol-rich lipoprotein X (LpX)1. Renal failure is a major cause of mortalityS1.