Proteasome inhibition affects RNAPII binding. Heat maps showing differential signal for non-phosphorylated (Non-P), and serine-5 phosphorylated (Ser5P) RNAPII at DOCRs that increase (GAIN; A) and decrease (LOST; B) accessibility. Signal spans ±1 kb from the center of the DOCRs and is ranked on the basis of the degree of change in accessibility. C, Metaplots for ChIP-seq binding signals of Non-P and Ser5P RNAPII at DOCRs. Signal includes the untreated state (0) and after 4H and 24H of treatment.
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Kinyamu et al. (2024) studied this question.
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