Mp49-12 Is Prostate Cancer Harboring Cribriform Pattern Visible on Multiparametric Mri?

You have accessJournal of UrologyProstate Cancer: Detection subdivided further into small and large pattern (glands with≥12 lumina). Predictors of visible CSPCa were assessed by multivariable logistic regression. Statistical significance was defined as p<0.05. RESULTS: Out of 148 patients, 112(76%) had visible CSPCa. CB was identified in 63 (43%) patients of those, 51 (81%) were detected on TB (visible on mpMRI). Patients with MRI visible CSPCa showed a higher median age (69 vs 67 yr, p=0.03); PSA (7.9 vs 5.9 ng/mL, p=0.006); PSA density (PSAD, 0.19 vs 0.14 ng/mL2, p=0.12); clinical T stage; T1 (43% vs 71%), T2 (38% vs 23%), and T3 (19% vs 6%) (p=0.01); rate of aggressive PCa: GG 2 (36% vs 72%), GG3 (29% vs 22%), GG4 (25% vs 0%), and GG5 (9% vs 6%) (p<0.001); number of cancer positive cores (7 vs 6, p=0.02); and maximum cancer core length (MCCL) (9 vs 7 mm, p<0.001), respectively. On multivariable analysis, GG 3-5 vs 2 (hazard ratio HR 4.68, 95% CI 2.05-10.68) and MCCL (HR 1.16, 95% CI 1.03-1.31) were independent predictors for MRI visible CSPCa; however, the presence of CB was not (HR 0.75, 95% CI 0.28-1.99). In patients with CB PCa, the presence of a large subtype of CB (HR 6.65, 95% CI 1.36-32.46) was an independent predictor for MRI visibility. CONCLUSIONS: Majority (81%) of CSPCa harboring Cribriform pattern are visible on mpMRI, however the MRI visibility seems to be associated with higher aggressiveness of the PCa and larger PCa volume. Less aggressive and lower volume PCa containing Cribriform pattern may not be visible on mpMRI. However, among the patients with cribriform, the presence of a large cribriform subtype is an independent predictor for MRI visibility. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e787 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Divyangi Paralkar More articles by this author Masatomo Kaneko More articles by this author Lorenzo Storino Ramacciotti More articles by this author Atsuko Fujihara More articles by this author Tsuyoshi Iwata More articles by this author Akash Sali More articles by this author Chhavi Gupta More articles by this author Giovanni Cacciamani More articles by this author Manju Aron More articles by this author Michelle Hopstone More articles by this author Inderbir Gill More articles by this author Andre Abreu More articles by this author Expand All Advertisement PDF downloadLoading ...