Mp08-20 Significant Drop of Early and Two-Yr Mortality for Bladder Cancer Patients Receiving Radical Cystectomy in the Last 20 Years: Single Center Analysis

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I (MP08)1 May 2024MP08-20 SIGNIFICANT DROP OF EARLY AND TWO-YR MORTALITY FOR BLADDER CANCER PATIENTS RECEIVING RADICAL CYSTECTOMY IN THE LAST 20 YEARS: SINGLE CENTER ANALYSIS Flavia Proietti, Aldo Brassetti, Rocco Simone Flammia, Gabriele Tuderti, Riccardo Mastroianni, Alfredo M. Bove, Umberto Anceschi, Salvatore Guaglianone, Mariaconsiglia Ferriero, Leonardo Misuraca, Simone D'Annunzio, Costantino Leonardo, and Giuseppe Simone Flavia ProiettiFlavia Proietti , Aldo BrassettiAldo Brassetti , Rocco Simone FlammiaRocco Simone Flammia , Gabriele TudertiGabriele Tuderti , Riccardo MastroianniRiccardo Mastroianni , Alfredo M. BoveAlfredo M. Bove , Umberto AnceschiUmberto Anceschi , Salvatore GuaglianoneSalvatore Guaglianone , Mariaconsiglia FerrieroMariaconsiglia Ferriero , Leonardo MisuracaLeonardo Misuraca , Simone D'AnnunzioSimone D'Annunzio , Costantino LeonardoCostantino Leonardo , and Giuseppe SimoneGiuseppe Simone View All Author Informationhttps://doi.org/10.1097/01.JU.0001008780.87855.57.20AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The purpose of the study is to assess the trends of 30-days and 2-year mortality in patients receiving radical cystectomy (RC) at a National Cancer Institute along a twenty-year time frame. METHODS: A single institution prospectively maintained database was queried to identify patients treated with RC for bladder cancer (BCa) from 2001 to 2020. Jointpoint regression analysis was used to assess the trends in both 30-d and 2-yr mortality rates. A Cox regression analyses was performed to identify predictors of 2-yr mortality and subsequently a crosstab analysis was performed to investigate potential differences in distribution of predictors over time. RESULTS: Overall, out of 1987 patients treated, follow-up data were available for 1895 patients. The baseline characteristics showed a median age of 68 (61-74) years and a male predominance (80%); 33.8% of patients were categorized as ASA ≥3, and pathologic non-organ-confined disease was found in 51.3% of patients. Either 30-day mortality (APC -8.63, slope p<0.001) or 2-year mortality rates (APC -5.8, slope p=0.02) displayed a trend towards significant decrease over time. On multivariable Cox regression analysis, pT stage was the only predictor of 2-year mortality, while baseline eGFR <60 ml/min and ASA score ≥3 showed a trend towards significance. At cross-tab analysis, these variables were homogeneously distributed along the years. CONCLUSIONS: In the last 20-years both 30-day and 2-year mortality rates of patients treated with RC displayed a significant decrease over time; these differences seem to be not related to baseline patients comorbidities and tumor stage. Further investigation on nationwide databases are needed to confirm the hypothesis that a higher quality of care has been delivered along the last two decades. Download PPT Source of Funding: The authors did not receive support from any organization for the submitted work © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e124 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Flavia Proietti More articles by this author Aldo Brassetti More articles by this author Rocco Simone Flammia More articles by this author Gabriele Tuderti More articles by this author Riccardo Mastroianni More articles by this author Alfredo M. Bove More articles by this author Umberto Anceschi More articles by this author Salvatore Guaglianone More articles by this author Mariaconsiglia Ferriero More articles by this author Leonardo Misuraca More articles by this author Simone D'Annunzio More articles by this author Costantino Leonardo More articles by this author Giuseppe Simone More articles by this author Expand All Advertisement PDF downloadLoading ...