Pd43-01 Structural Changes in Brain White Matter Tracts Associated With Overactive Bladder Revealed by Diffusion Tensor Mri: Findings From the Lurn Study

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Overactive Bladder I (PD43)1 May 2024PD43-01 STRUCTURAL CHANGES IN BRAIN WHITE MATTER TRACTS ASSOCIATED WITH OVERACTIVE BLADDER REVEALED BY DIFFUSION TENSOR MRI: FINDINGS FROM THE LURN STUDY H. Henry Lai, Jerrel Rutlin, Abigail R. Smith, Margaret E. Helmuth, James A. Hokanson, Claire C. Yang, J. Quentin Clemens, Vincent A. Magnotta, C. Emi Bretschneider, Kimberly Kenton, John O. L. DeLancey, Karen John, Ziya Kirkali, and Joshua S. Shimony H. Henry LaiH. Henry Lai , Jerrel RutlinJerrel Rutlin , Abigail R. SmithAbigail R. Smith , Margaret E. HelmuthMargaret E. Helmuth , James A. HokansonJames A. Hokanson , Claire C. YangClaire C. Yang , J. Quentin ClemensJ. Quentin Clemens , Vincent A. MagnottaVincent A. Magnotta , C. Emi BretschneiderC. Emi Bretschneider , Kimberly KentonKimberly Kenton , John O. L. DeLanceyJohn O. L. DeLancey , Karen JohnKaren John , Ziya KirkaliZiya Kirkali , and Joshua S. ShimonyJoshua S. Shimony View All Author Informationhttps://doi.org/10.1097/01.JU.0001009568.19060.25.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Functional MRI studies have revealed that several brain regions contribute to overactive bladder (OAB). Communication between these cortical gray matter regions relies on the structural integrity of underlying white matter tracts or pathways that connect these cortical areas. The objectives of this study are to investigate: 1) if OAB patients will demonstrate abnormalities in brain white matter tracts compared to controls; and 2) if the degree of microstructural changes in brain white matter tracts will correlate to their OAB symptoms. METHODS: Treatment seeking OAB patients and matched controls enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Neuroimaging Study received a brain DTI scan. Microstructural integrity of brain white matter was assessed using fractional anisotropy (FA) and mean diffusivity (MD), and these were compared between OAB and controls. OAB and urgency urinary incontinence (UUI) symptoms were assessed using OAB-q, ICIQ-UI and the LUTS Tool, and their responses were correlated with FA values. RESULTS: Among the 221 participants with evaluable DTI data, 146 had OAB (66 urinary urgency UU only without UUI, 80 with UUI) and 75 were controls. Compared to controls, participants with OAB showed decreased FA and increased MD, representing greater microstructural abnormalities of brain white matter tracts among OAB participants. These abnormalities occurred in the corpus callosum, bilateral anterior thalamic radiation (ATR) and superior longitudinal fasciculus (SLF) tracts, and bilateral insula and para-hippocampal region (PHC). See Figure. Among participants with OAB, higher OAB-q scores were associated with decreased FA or increased microstructural abnormalities of brain white matter tracts in the left inferior fronto-occipital fasciculus (IFOR), p<0.0001. The DTI differences between OAB and controls were driven by the UU only without UUI subgroup (OAB-dry), but not the UUI (OAB-wet) subgroup. CONCLUSIONS: Treatment seeking patients with OAB showed abnormalities in microstructural integrity in specific brain white matter tracts that correlated with their OAB symptoms. Patients with urinary urgency only without UUI (OAB-dry) may have different neuro-pathophysiology than those with UUI (OAB-wet). Download PPT Source of Funding: LURN is supported by the NIH/NIDDK © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e898 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information H. Henry Lai More articles by this author Jerrel Rutlin More articles by this author Abigail R. Smith More articles by this author Margaret E. Helmuth More articles by this author James A. Hokanson More articles by this author Claire C. Yang More articles by this author J. Quentin Clemens More articles by this author Vincent A. Magnotta More articles by this author C. Emi Bretschneider More articles by this author Kimberly Kenton More articles by this author John O. L. DeLancey More articles by this author Karen John More articles by this author Ziya Kirkali More articles by this author Joshua S. Shimony More articles by this author Expand All Advertisement PDF downloadLoading ...