MP61-10 A PROPOSED SUB-CLASSIFICATION OF pN3 STAGE OF SQUAMOUS CELL CARCINOMA OF PENIS

You have accessJournal of UrologyPenile & Testicular Cancer II (MP61)1 May 2024MP61-10 A PROPOSED SUB-CLASSIFICATION OF pN3 STAGE OF SQUAMOUS CELL CARCINOMA OF PENIS Keval N. Patel, Mohit N. Sharma, Poojitha N. Yalla, Abhijeet N. Salunke, Vikas N. Warikoo, Shivam N. Pandya, Ketul N. Puj, and Shashank J. Pandya Keval N. PatelKeval N. Patel , Mohit N. SharmaMohit N. Sharma , Poojitha N. YallaPoojitha N. Yalla , Abhijeet N. SalunkeAbhijeet N. Salunke , Vikas N. WarikooVikas N. Warikoo , Shivam N. PandyaShivam N. Pandya , Ketul N. PujKetul N. Puj , and Shashank J. PandyaShashank J. Pandya View All Author Informationhttps://doi.org/10.1097/01.JU.0001009536.58867.87.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To evaluate the differential prognosis of PLNM as compared to ENE and postulate a sub-classification of the pN3 stage of carcinoma penis. METHODS: A retrospective analysis of prospectively maintained data of all the patients of penile squamous cell carcinoma operated at our institute between Jan 2016 and May 2023 was conducted. LASSO Cox regression was used to select variables affecting OS. Cox multivariate analysis was performed to derive significant factors which were permuted to form probable sub-classifications. The best sub-classification was selected based on Akaike Information Criteria (AIC) and Kaplan Meier analysis. RESULTS: Seventy three patients were included in the study. ENE, PLNM and adjuvant therapy had a significant association with OS on LASSO Cox regression analysis. ENE (HR: 3.371, p=0.005) and PLNM (HR: 4.058, p=0.001) were significantly associated with OS on Cox univariate and multivariate analysis. Four probable sub-classifications were created of which pN3a (only ENE) and pN3b (only PLNM and ENE+PLNM) showed least AIC (235.065). The mean OS was 36.6months and 17.2months respectively for pN3a and pN3b subgroups. CONCLUSIONS: A sub-classification of pN3 stage of TNM classification is proposed. Multi-institutional prospective studies with large number of patients and longer followup should validate our findings. The subgrouping will have future implications in planning follow-up strategies, planning adjuvant therapies and designing future studies. Download PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1013 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Keval N. Patel More articles by this author Mohit N. Sharma More articles by this author Poojitha N. Yalla More articles by this author Abhijeet N. Salunke More articles by this author Vikas N. Warikoo More articles by this author Shivam N. Pandya More articles by this author Ketul N. Puj More articles by this author Shashank J. Pandya More articles by this author Expand All Advertisement PDF downloadLoading ...