Pd31-04 Rates of Penile Fracture and Peyronie’s Disease in Patients With Connective Tissue Disorders

You have accessJournal of UrologyReconstruction: External Genitalia and Urotrauma (including transgender surgery and traumatic fistula) I (PD31)1 May 2024PD31-04 RATES OF PENILE FRACTURE AND PEYRONIE'S DISEASE IN PATIENTS WITH CONNECTIVE TISSUE DISORDERS Rishabh K. Simhal, Asher Mandel, Tamir N. Sholklapper, Kerith R. Wang, Yash B. Shah, Kelly Sun, Maria Poluch, and Paul C. Chung Rishabh K. SimhalRishabh K. Simhal , Asher MandelAsher Mandel , Tamir N. SholklapperTamir N. Sholklapper , Kerith R. WangKerith R. Wang , Yash B. ShahYash B. Shah , Kelly SunKelly Sun , Maria PoluchMaria Poluch , and Paul C. ChungPaul C. Chung View All Author Informationhttps://doi.org/10.1097/01.JU.0001009432.48553.4f.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Ehlers Danlos Syndrome (EDS) and collagen-related hypermobility disorders are well known to cause frequent joint dislocations, easy bruising, and poor wound healing. Marfan syndrome is caused by a mutation in the protein fibrillin, a key component of collagen and elastin connective tissue, whose dysfunction causes the marfanoid phenotype. Currently, little is known regarding the impact of connective tissue disorders on men's sexual health. Therefore, we investigated two physical phenomena that may be impacted by collagen disorders, penile fractures and Peyronie's disease. This study aims to investigate rates of penile fracture and Peyronie's disease in EDS and Marfan syndrome patients. METHODS: A multi-center, international, electronic health record network (TriNetX) was queried to identify adult male patients with or without EDS from 1993-2023 using ICD-10 codes for EDS and EDS related hypermobility syndrome. TriNetX was separately queried for Marfan syndrome. Using ICD-10 codes again, incidence and prevalence of penile fractures and Peyronie's disease were compared between patients with and without the connective tissue disorders. Odds ratios were generated with 95% confidence intervals. All statistical analyses were conducted within the TriNetX platform. RESULTS: Data was queried from 82 healthcare organizations to yield 11,937 EDS patients, and from 101 healthcare organizations to yield 13,705 Marfan syndrome patients. 109 healthcare organizations contributed data to yield a control group of 63,790,628 men. Men with EDS had a 25 times higher rate of penile fractures (0.09%) compared to men without EDS (OR 25; 95% CI [13.8-47.8]). Men with Marfan's syndrome had a 23 times higher rate of penile fractures (0.08%) compared to men without Marfan's syndrome (OR 23; 95% CI [12.4-43.1]). Men with Marfan's syndrome also had a significantly higher incidence of Peyronie's disease compared to men without Marfan's syndrome (OR 1.9; 95% CI [1.2-3]). The difference in rates of Peyronie's disease was not significantly higher for men with EDS (OR 1.4; 95% CI [0.8–2.5]). CONCLUSIONS: Patients with EDS and Marfan syndrome are at an over 20 times higher risk for penile fracture. These increased risks may be due to EDS's and Marfan syndrome's effects on collagen and fibrillin/elastic fibers, respectively, which are significant structural components of the corpora cavernosa. Patients with these syndromes should be aware of this increased risk and further research is needed to establish how to council these patients about taking appropriate precautions. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e631 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Rishabh K. Simhal More articles by this author Asher Mandel More articles by this author Tamir N. Sholklapper More articles by this author Kerith R. Wang More articles by this author Yash B. Shah More articles by this author Kelly Sun More articles by this author Maria Poluch More articles by this author Paul C. Chung More articles by this author Expand All Advertisement PDF downloadLoading ...