MP66-11 COMPARISON OF THE BIO-MECHANICAL PROPERTIES OF HUMAN AND BABOON’s TUNICA ALBUGINEA

You have accessJournal of UrologySexual Function/Dysfunction: Basic Research & Pathophysiology (MP66)1 May 2024MP66-11 COMPARISON OF THE BIO-MECHANICAL PROPERTIES OF HUMAN AND BABOON's TUNICA ALBUGINEA Alberto Colombo, Sarang Janakiraman, Eric Chuang, Alexander Kandabarow, Brian Le, and Kevin Thomans McVary Alberto ColomboAlberto Colombo , Sarang JanakiramanSarang Janakiraman , Eric ChuangEric Chuang , Alexander KandabarowAlexander Kandabarow , Brian LeBrian Le , and Kevin Thomans McVaryKevin Thomans McVary View All Author Informationhttps://doi.org/10.1097/01.JU.0001009468.01097.19.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The penis is in its essence a biomechanical implement and the Tunica Albuginea is the main load-bearing tissue during erection and its biomechanical properties are critical to understanding the penile physiology and the expansion of corpora cavernosa. There is surprisingly a paucity of data surrounding the biomechanical properties of the (TA) in literature. We previously quantified the Young's modulus and ultimate tensile strength (UTS) of TA in primates and we now compare these values with human TA tissue. METHODS: Strips of TA were dissected from patients undergoing penectomy in both longitudinal and circumferential orientations. We generated stress-strain curves via mechanical extensometry using an Instron machine. From this curve the Young's modulus (a measure of stiffness), ultimate tensile strength and Poisson ratios (the ratio between lateral and longitudinal strain) were calculated. Comparisons between human and baboon values were performed with a t-test. RESULTS: Six samples from 3 penes produced a mean Young's modulus of 8.1 MPa (SD 1.7) longitudinally (n=3) and 10.3 MPa (SD 3.1) circumferentially (n=4). The mean ultimate tensile strength was 1.8 MPa (SD 0.6) longitudinally and 1.7 MPa (SD 0.1 MPa) circumferentially. These values show that human tunica albuginea has a stiffness between cartilage and cancellous bone. In comparison with baboons (Papio anubis), human samples had a lower Young's modulus longitudinally (8.1 vs 34.0, p<0.01) but not circumferentially (10.3 vs 11.7, p=0.32). Additionally, the human samples had a lower maximum stress longitudinally (1.8 vs 4.3, p=0.01) but not circumferentially (1.7 vs 2.0, p=0.29). These data show that baboon TA is stiffer and stronger longitudinally than human TA. Poisson ratio was between 0.87 and 1.23 with variability lower than 0.20. No specific difference between longitudinal and radial specimens was measured. CONCLUSIONS: These measures of fresh human TA show some variation between human and primate models and support the need for fresh human tissue measurements to characterize the mechanical properties of the penis. These data will be critical in developing in silico models that can be used to investigate mechanical disease states of the penis and predict tissue/prosthesis interactions. Download PPT Source of Funding: Loyola University internal grant © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1089 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Alberto Colombo More articles by this author Sarang Janakiraman More articles by this author Eric Chuang More articles by this author Alexander Kandabarow More articles by this author Brian Le More articles by this author Kevin Thomans McVary More articles by this author Expand All Advertisement PDF downloadLoading ...