Mp71-07 the Impact of Centralized Uropathology Review in the Management of Bladder Cancer Patients at the Time of Transurethral Resection of the Bladder

You have accessJournal of UrologyBladder Cancer: Non-invasive IV (MP71)1 May 2024MP71-07 THE IMPACT OF CENTRALIZED UROPATHOLOGY REVIEW IN THE MANAGEMENT OF BLADDER CANCER PATIENTS AT THE TIME OF TRANSURETHRAL RESECTION OF THE BLADDER Daniele Robesti, Marco Moschini, Nazario Pio Tenace, Giusy Burgio, Chiara Re, R.Iccardo Leni, Mario De Angelis, Pietro Scilipoti, Francesco Pellegrino, Donato Cannoletta, Giorgio Gandaglia, Nicola Fossati, Andrea Gallina, Claudio Doglioni, Maurizio Colecchia, Andrea Salonia, Francesco Montorsi, Alberto Briganti, and Roberta Lucianò Daniele RobestiDaniele Robesti , Marco MoschiniMarco Moschini , Nazario Pio TenaceNazario Pio Tenace , Giusy BurgioGiusy Burgio , Chiara ReChiara Re , R.Iccardo LeniR.Iccardo Leni , Mario De AngelisMario De Angelis , Pietro ScilipotiPietro Scilipoti , Francesco PellegrinoFrancesco Pellegrino , Donato CannolettaDonato Cannoletta , Giorgio GandagliaGiorgio Gandaglia , Nicola FossatiNicola Fossati , Andrea GallinaAndrea Gallina , Claudio DoglioniClaudio Doglioni , Maurizio ColecchiaMaurizio Colecchia , Andrea SaloniaAndrea Salonia , Francesco MontorsiFrancesco Montorsi , Alberto BrigantiAlberto Briganti , and Roberta LucianòRoberta Lucianò View All Author Informationhttps://doi.org/10.1097/01.JU.0001009548.76580.ba.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Pathological features in non-muscle invasive bladder cancer specimens are pivotal in determining correct patients' therapeutical management. Sparse data exists regarding the importance of second opinion performed by an expert uropathologist. METHODS: The study relied on 272 bladder cancer specimens from 231 patients seeking a pathology second opinion after transurethral resection of the bladder (TURBT) for clinical suspicion of bladder cancer, relapse, or a second look procedure. Pathology second opinion was offered by an experienced fellowship-trained uropathologist. Discrepancies were recorded considering primary tumor staging, the presence of muscularis propria, and of histological variants. Cases were categorized as no significant discordance, major discordance without management change, and major discordance with management change according to the European Urology Association (EAU) guidelines. RESULTS: Among 272 second-opinion cases, 39% (108/272) had major discordance and 28% (75/272) had major discordance with change in management according to EAU guidelines. Upstaging and downstaging were reported in 66 (24%) patients. Improper identification of muscularis propria presence was found in 46 (17%) cases, of which 11 (4%) were deemed clinically relevant. Differences regarding histological variants presence were diagnosed in 40 cases (15%), resulting in 8 changes in clinical management. In 10 specimens (4%), multiple clinically relevant discrepancies were found. CONCLUSIONS: The second-opinion evaluation changed the clinical management in 25% of the cases. These results support the importance of centralized read performed by an expert uropathologist as a major driver in the correct bladder cancer management. Source of Funding: - © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1163 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Daniele Robesti More articles by this author Marco Moschini More articles by this author Nazario Pio Tenace More articles by this author Giusy Burgio More articles by this author Chiara Re More articles by this author R.Iccardo Leni More articles by this author Mario De Angelis More articles by this author Pietro Scilipoti More articles by this author Francesco Pellegrino More articles by this author Donato Cannoletta More articles by this author Giorgio Gandaglia More articles by this author Nicola Fossati More articles by this author Andrea Gallina More articles by this author Claudio Doglioni More articles by this author Maurizio Colecchia More articles by this author Andrea Salonia More articles by this author Francesco Montorsi More articles by this author Alberto Briganti More articles by this author Roberta Lucianò More articles by this author Expand All Advertisement PDF downloadLoading ...