Mp01-01 Incremental Dose-Response Effect of Age on Mortality in Non-Seminoma Testis Cancer Patients

You have accessJournal of UrologyPenile & Testicular Cancer I (MP01)1 May 2024MP01-01 INCREMENTAL DOSE-RESPONSE EFFECT OF AGE ON MORTALITY IN NON-SEMINOMA TESTIS CANCER PATIENTS Reha-Baris Incesu, Mattia Luca Piccinelli, Simone Morra, Lukas Scheipner, Stefano Tappero, Francesco Barletta, Cristina Cano Garcia, Zhe Tian, Fred Saad, Shahrokh F. Shariat, Felix K. H. Chun, Alberto Briganti, Carlo Terrone, Sascha Ahyai, Nicola Longo, Ottavio de Cobelli, Derya Tilki, Markus Graefen, and Pierre I. Karakiewicz Reha-Baris IncesuReha-Baris Incesu , Mattia Luca PiccinelliMattia Luca Piccinelli , Simone MorraSimone Morra , Lukas ScheipnerLukas Scheipner , Stefano TapperoStefano Tappero , Francesco BarlettaFrancesco Barletta , Cristina Cano GarciaCristina Cano Garcia , Zhe TianZhe Tian , Fred SaadFred Saad , Shahrokh F. ShariatShahrokh F. Shariat , Felix K. H. ChunFelix K. H. Chun , Alberto BrigantiAlberto Briganti , Carlo TerroneCarlo Terrone , Sascha AhyaiSascha Ahyai , Nicola LongoNicola Longo , Ottavio de CobelliOttavio de Cobelli , Derya TilkiDerya Tilki , Markus GraefenMarkus Graefen , and Pierre I. KarakiewiczPierre I. Karakiewicz View All Author Informationhttps://doi.org/10.1097/01.JU.0001008660.87408.90.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Age ≥40 predisposes to higher testis cancer-specific mortality (CSM) in non-seminoma. However, it is unknown, whether an incremental dose-response effect applies to subgroups of testis cancer patients (tertiles aged ≥40). We tested this hypothesis in contemporary non-seminoma patients. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database (2004−2018) was used. Kaplan-Meier plots and multivariable Cox regression models tested the effect of age on CSM after stratification for stage (I vs. II vs. III). RESULTS: Of 13,679 non-seminoma patients, 11,034 (81%) were aged<40 vs. 2,645 (19%) were aged ≥40. Of patients aged ≥40, 943 were aged 40-44 (young age tertile) vs. 855 were aged 45-52 (intermediate age tertile) vs. 847 were aged ≥53 (old age tertile). In overall multivariable analyses relative to patients aged <40, young age tertile (HR 1.4, p<0.01), intermediate age tertile (HR 1.9, p<0.001) and old age tertile (HR 3.6, p<0.001) were associated with higher CSM. In stage-specific multivariable analyses relative to patients aged <40, old age tertile predicted higher CSM in stage I (HR 4.7, p<0.001), stage II (HR 9.9, p<0.001) and stage III (HR 3.0, p<0.001). In stage III, intermediate age tertile (HR 1.9, p<0.001) and young age tertile (HR 1.5, p=0.007) also predicted higher CSM. CONCLUSIONS: We identified a dose-response effect of increasing age in non-seminoma patients aged ≥40, in the overall analysis as well as in stage-specific analyses. Download PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Reha-Baris Incesu More articles by this author Mattia Luca Piccinelli More articles by this author Simone Morra More articles by this author Lukas Scheipner More articles by this author Stefano Tappero More articles by this author Francesco Barletta More articles by this author Cristina Cano Garcia More articles by this author Zhe Tian More articles by this author Fred Saad More articles by this author Shahrokh F. Shariat More articles by this author Felix K. H. Chun More articles by this author Alberto Briganti More articles by this author Carlo Terrone More articles by this author Sascha Ahyai More articles by this author Nicola Longo More articles by this author Ottavio de Cobelli More articles by this author Derya Tilki More articles by this author Markus Graefen More articles by this author Pierre I. Karakiewicz More articles by this author Expand All Advertisement PDF downloadLoading ...