MP59-09 ONE STEP CLOSER TO a CATHETER-FREE PRESSURE FLOW STUDY: SUBHARMONIC-AIDED PRESSURE ESTIMATION OF HUMAN BLADDERS USING CONTRAST ULTRASONOGRAPHY

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology (MP59)1 May 2024MP59-09 ONE STEP CLOSER TO a CATHETER-FREE PRESSURE FLOW STUDY: SUBHARMONIC-AIDED PRESSURE ESTIMATION OF HUMAN BLADDERS USING CONTRAST ULTRASONOGRAPHY Kourosh Kalayeh, J. Brian Fowlkes, John O. DeLancey, James A. Ashton-Miller, William W. Schultz, and Bryan S. Sack Kourosh KalayehKourosh Kalayeh , J. Brian FowlkesJ. Brian Fowlkes , John O. DeLanceyJohn O. DeLancey , James A. Ashton-MillerJames A. Ashton-Miller , William W. SchultzWilliam W. Schultz , and Bryan S. SackBryan S. Sack View All Author Informationhttps://doi.org/10.1097/01.JU.0001009476.18935.3b.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Urodynamic tests require a urethral catheter resulting in non-physiologic pressure flow measurements. We have previously shown that an ultrasound-based technology, known as subharmonic-aided pressure estimation (SHAPE), can effectively measure pressure in a bladder phantom. In this study, we measure bladder pressure using this technology in adult female volunteers. We hypothesize that SHAPE may be a viable alternative for measuring bladder pressure non-invasively. METHODS: The urodynamic tests were performed with a standard urodynamic system. The GE Healthcare LOGIQ® E10 ultrasound scanner equipped with the SHAPE mode and the C2-9 probe was used for ultrasound scanning. Lumason® ultrasound contrast agent was diluted in normal saline at a 500:1 dilution and infused via the urodynamic system. The bladders were filled from an initial volume of 60 to 270 mL at a filling rate of 30 mL/min. During the test the bladder was pressurized through Valsalva maneuvers by the subject (pressurization event). Probe location differences were assessed on the abdomen and perineum. The pressure values from the urodynamics catheter and the subharmonic signals were recorded for offline analysis to determine the SHAPE conversion factor in dB/cmH2O. RESULTS: We observed an inverse linear relationship between SHAPE signal and changes in bladder pressure during filling and post filling, for both transabdominal and transperineal imaging. The accompanying figure serves as an illustrative example of these findings. For this example, SHAPE conversion factors are −0.06 and −0.08 dB/cmH2O with R2=0.86 and 0.93 for transabdominal and transperineal orientations, respectively. CONCLUSIONS: Based on these preliminary human subject findings, our study shows the potential of SHAPE as a catheter-free viable alternative for measuring bladder pressure. SHAPE can measure changes in bladder pressure during filling and post-filling in both transabdominal and transperineal imaging modes. These initial findings are promising but require further validation to confirm SHAPE's efficacy and clinical applicability during voiding. Download PPT Source of Funding: Supported by NIH-RC2-DK-122379 © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e960 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Kourosh Kalayeh More articles by this author J. Brian Fowlkes More articles by this author John O. DeLancey More articles by this author James A. Ashton-Miller More articles by this author William W. Schultz More articles by this author Bryan S. Sack More articles by this author Expand All Advertisement PDF downloadLoading ...