Mp28-08 Combined Therapy With Low-Intensity Shockwave Therapy and Daily Pde5i Showed Better Pain Relieve and Sexual Function Improvement in Acute Phase of Peyronie Disease

You have accessJournal of UrologySexual Function/Dysfunction: Peyronie's Disease (MP28)1 May 2024MP28-08 COMBINED THERAPY WITH LOW-INTENSITY SHOCKWAVE THERAPY AND DAILY PDE5I SHOWED BETTER PAIN RELIEVE AND SEXUAL FUNCTION IMPROVEMENT IN ACUTE PHASE OF PEYRONIE DISEASE Shi Ran Xu, Yan Ping Huang, and Mujun Lu Shi Ran XuShi Ran Xu , Yan Ping HuangYan Ping Huang , and Mujun LuMujun Lu View All Author Informationhttps://doi.org/10.1097/01.JU.0001008872.42208.7a.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To compare the efficacy and safety of daily use PDE5i and PDE5i combined with linear low-intensity shockwave therapy (Li-SWT) in the treatment of acute phase of Peyronie disease (PD). METHODS: 68 patients with acute PD within 6 month onset were collected. The patients were 26-56 years old with an average of 42.3 years. The patients were randomly divided into two groups, 35 of which were orally administered with 5 mg of tadalafil every night for 3 months; the other 33 received 4 times of Li-SWT with daily PDE5i. Li-SWT uses the Renova shock wave therapy device with an energy density of 0.09 mJ/mm2, each time 3200 times in the penile plaque, 900 times in the left and right penile shaft, and once a week for 4 consecutive treatments as a cycle. All patients underwent ultrasound or MRI, penile bending angle measurement, improvement of subjective symptoms, and IIEF-5 scale before and after treatment. RESULTS: In the PDE5i group, the pain symptom relieve were improved in 80% patients (28 of 35 cases), while the combined group (PDE5i+Li-SWT) were improved in 90.9% patients (30 of 33 cases). The IIEF5 score in the PDE5i group improved from 13.8±7.9 to 19.5±8.1 and from 13.4±7.6 to 21.3±9.2 in the combined group, with both improvement between two groups. The plaque size were shrinkage 5 cases in PDE5i group and 12 cases in combined group, but penile curvature did not change significantly in both groups. In the PDE5i group, 5 patients had mild dizziness and back pain, while 3 patients had mild dizziness and back pain in combined group. There was no obvious adverse reaction observed for Li-SWT treatment. CONCLUSIONS: Both the daily use PDE5i and the PDE5i combined with Li-SWT can improve the symptoms of acute PD patients, mainly to relieve pain and improve erectile function in some patients. The combined group had a better pain symptom relieve rate and more improvement for sexual function. The two methods can reduce PD plaque size in some cases, while both groups did not significantly change penile curvature. Both methods have good safety in the treatment of acute phase PD. Source of Funding: The National Natural Science Foundation of China (82171611,81971376,82371631) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e475 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Shi Ran Xu More articles by this author Yan Ping Huang More articles by this author Mujun Lu More articles by this author Expand All Advertisement PDF downloadLoading ...