Mp74-19 High Glut1 Membrane Expression and Low Psma Membrane Expression in Ductal Adenocarcinoma and Intraductal Carcinoma of the Prostate

You have accessJournal of UrologyProstate Cancer: Detection & Screening VI (MP74), Moderated Poster 741 May 2024MP74-19 HIGH GLUT1 MEMBRANE EXPRESSION AND LOW PSMA MEMBRANE EXPRESSION IN DUCTAL ADENOCARCINOMA AND INTRADUCTAL CARCINOMA OF THE PROSTATE Xingming Wang, Li Zhou, Lin Qi, Ye Zhang, Hongling Yin, Yu Gan, Xiaomei Gao, and Yi Cai Xingming WangXingming Wang , Li ZhouLi Zhou , Lin QiLin Qi , Ye ZhangYe Zhang , Hongling YinHongling Yin , Yu GanYu Gan , Xiaomei GaoXiaomei Gao , and Yi CaiYi Cai View All Author Informationhttps://doi.org/10.1097/01.JU.0001008632.59099.b9.19AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Both Ductal Adenocarcinoma (DAC) and Intraductal Carcinoma (IDC) of the prostate are generally associated with aggressive clinical behavior and poor prognosis and can be lethal. Furthermore, previous studies linked aggressive clinical behavior and poor prognosis with discordant FDG positivity and low Prostate-specific membrane antigen (PSMA) expression. A recent study only cited a DAC patient with low 68Ga-PSMA-11 PET/CT uptake but high 18F-FDG PET/CT uptake, however, there is lack of directly compared articles nor large data sets. IDC-P is a mean differential diagnosis for DAC. Hence, the objective of this study was to investigate the expression of PSMA and GLUT1 in DAC and IDC-P patients. METHODS: The study was conducted on 87 DAC or IDC-P patients without any treatment and 97 PAC patients with a Gleason score ≥8 of prostate biopsies and prostatectomy samples between August 2017 and August 2022. We performed immunohistochemical staining and scoring of various cancer component samples from the patients to reflect the protein expression levels of PSMA and GLUT1. RESULTS: PSMA expression in PAC tissues was significantly higher than in DAC/IDC-P tissues (141.2 vs 78.6, p<0.001). There was no significant difference in PSMA membrane expression between DAC/IDC-P and adjacent acinar adenocarcinoma (78.6 vs 93.4, p=0.166). GLUT1 expression was higher in DAC/IDC-P tissue than in acinar adenocarcinoma tissue adjacent to DAC/IDC-P (68.6 vs 51.3, p=0.007), but was still lower than that in PAC tissue (68.6 vs 93.1, p=0.0014). It is worth noting that GLUT1 membrane expression in DAC/IDC-P was significantly increased than in PAC (13.0 vs 6.6, p=0.025), and in acinar adenocarcinoma adjacent to DAC/IDC-P (13.0 vs 2.0, p<0.001). CONCLUSIONS: In DAC and IDC-P tissues, PSMA membrane expression is low, while GLUT1 expression, especially GLUT1 membrane expression is high. These findings imply that DAC and IDC-P cells may have higher glucose metabolic and raise interest in targeting membrane GLUT1 as a novel anticancer strategy for DAC/IDC-P and other prostate cancer with high glucose metabolism. Source of Funding: This research was supported by National Natural Science Foundation of China (82272907,81974397), the key Research and Development program of Hunan Province(2021SK2014), National Key Research and Development Plan (2017YFC0908004), Clinical Big Data System Construction Project Fund of Xiangya Hospital (No. 33020125030) and the Xiangya Famous Doctor Fund of Central South University (33020123007) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1200 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Xingming Wang More articles by this author Li Zhou More articles by this author Lin Qi More articles by this author Ye Zhang More articles by this author Hongling Yin More articles by this author Yu Gan More articles by this author Xiaomei Gao More articles by this author Yi Cai More articles by this author Expand All Advertisement PDF downloadLoading ...