Mp13-10 Paternal Age Is Positively Correlated With Delay in Early Embryo Development

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation I (MP13)1 May 2024MP13-10 PATERNAL AGE IS POSITIVELY CORRELATED WITH DELAY IN EARLY EMBRYO DEVELOPMENT Rossella Cannarella, Sandrine Chamayou, Simona Romano, Scott D. Lundy, Sandro La Vignera, and Aldo E. Calogero Rossella CannarellaRossella Cannarella , Sandrine ChamayouSandrine Chamayou , Simona RomanoSimona Romano , Scott D. LundyScott D. Lundy , Sandro La VigneraSandro La Vignera , and Aldo E. CalogeroAldo E. Calogero View All Author Informationhttps://doi.org/10.1097/01.JU.0001008832.14212.d6.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Time-lapse monitoring has enabled rapid and reproducible assessment of embryo development and morphology, and early embryo kinetics have been found to influence the rate of blastocyst formation and clinical outcome. Paternal age is known to affect sperm motility, DNA fragmentation, and aneuploidy rate, all of which can potentially influence embryo development. To our knowledge, only one study has investigated the relationship between paternal age and early embryo development and reported delayed embryo development in older fathers using traditional intermittent asssessment. The objective of this study was to robustly examine the impact of male age on embryo morphokinetic parameters using the superior time lapse platform. METHODS: Data from 907 zygotes generated by 151 couples in a private assisted reproductive technique center were collected. The timing of specific events from the time of insemination were recorded, such as timing to appearance and fading pronuclei, two, three, four, five, six, seven, eight, and nine cells, and blastulation. Linear regression analysis was used to evaluate the influence of paternal age on embryo morphokinetic events. Multivariate analysis was performed to correct for the female partner's age, body mass index, and anti-Müllerian hormone (AMH). RESULTS: Linear regression analysis showed that paternal age was positively correlated with delayed cell cleavage and blastulation (Figure 1). After correction for confounding factors, the positive correlation was confirmed for the delayed timing of appearance and fading of pronuclei, two, eight cells, and blastulation (Table 1). CONCLUSIONS: Paternal age is weakly but positively correlated with delayed embryo cleavage and blastulation and may negatively impair ART outcomes through mechanisms that require further investigation. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e214 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Rossella Cannarella More articles by this author Sandrine Chamayou More articles by this author Simona Romano More articles by this author Scott D. Lundy More articles by this author Sandro La Vignera More articles by this author Aldo E. Calogero More articles by this author Expand All Advertisement PDF downloadLoading ...