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April 13, 2024Journal of Medicinal Chemistry

Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs

Yanying Sun Zhenzhen Zhou Na Wang Fabao Zhao Ying Liu Xiaoxuan Xu Xiaohan Wang Zhenbang Gou Erik De Clercq Christophe Pannecouque Peng Zhan Dongwei Kang Xinyong Liu

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Abstract

NNRTI is an important component of the highly active antiretroviral therapy (HAART), but the rapid emergence of drug resistance and poor pharmacokinetics limited their clinical application. Herein, a series of novel aryl triazolone dihydropyridines (ATDPs) were designed by structure-guided design with the aim of improving drug resistance profiles and pharmacokinetic profiles. Compound

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Sun et al. (2024) studied this question.

synapsesocial.com/papers/68e6f4bdb6db64358766f2a7 https://doi.org/10.1021/acs.jmedchem.4c00026

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