Epigenetic regulation by KDM5A mediates the effects of prenatal PM2.5 exposure on hippocampal development and synaptic integrity through the Shh signaling pathway

Jia Huang; Chao Song; Yongping Liu; Tianliang Zhang; Tingting Wang; Xinqi Liu; Yu Li

doi:10.1016/j.ecoenv.2024.116311

April 13, 2024Ecotoxicology and Environmental SafetyOpen Access

Epigenetic regulation by KDM5A mediates the effects of prenatal PM2.5 exposure on hippocampal development and synaptic integrity through the Shh signaling pathway

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Key Points

Epigenetic regulation by KDM5A mediates the harmful effects of prenatal PM2.5 exposure on hippocampal development, reducing synaptic integrity across vulnerable brain regions.
Molecular analysis evaluates prenatal PM2.5 exposure and indicates disruption of the Shh signaling pathway, linking maternal environmental exposure to altered neurodevelopment.
These insights highlight KDM5A as an epigenetic regulator of neurodevelopmental disorders following prenatal PM2.5 exposure, though further mechanistic validation is warranted.

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Implication

Experimental analysis reveals KDM5A-mediated impairment of hippocampal development from prenatal PM2.5 exposure, highlighting epigenetic mechanisms in neurodevelopmental risk.

Abstract

Prenatal environmental exposure could be an essential health risk factor associated with neurodevelopmental disorders in offspring. However, the exact mechanisms underlying the impact of prenatal PM

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Huang et al. (2024) studied this question.

synapsesocial.com/papers/68e6f4bdb6db64358766f4a7 https://doi.org/10.1016/j.ecoenv.2024.116311

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Epigenetic regulation by KDM5A mediates the effects of prenatal PM2.5 exposure on hippocampal development and synaptic integrity through the Shh signaling pathway

Key Points

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Implication

Abstract

Discussion

Cite This Study

Epigenetic regulation by KDM5A mediates the effects of prenatal PM2.5 exposure on hippocampal development and synaptic integrity through the Shh signaling pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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