Three new C 10 and C 12 aliphatic δ ‐lactones ( 1 – 3 ), three new fatty acid methyl esters ( 4 – 6 ), and eight known compounds ( 7 – 14 ) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS‐induced BV‐2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC 50 value of 120.3 nM.
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