Genetic Insights into E-Cadherin Modulation: Exploring the Benefits of Synthetic Acetyl Hexapeptide-1 in Wound Healing and Anti-Aging for Dermo-Cosmetics

first_page Download PDF settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Genetic Insights into E-Cadherin Modulation: Exploring the Benefits of Synthetic Acetyl Hexapeptide-1 in Wound Healing and Anti-Aging for Dermo-Cosmetics † by Nikoleta TopouzidouNikoleta Topouzidou SciProfiles Scilit Preprints.org Google Scholar , Christos PetrouChristos Petrou SciProfiles Scilit Preprints.org Google Scholar , Androulla N. MiliotouAndroulla N. Miliotou SciProfiles Scilit Preprints.org Google Scholar * and Yiannis SarigiannisYiannis Sarigiannis SciProfiles Scilit Preprints.org Google Scholar * Department of Health Sciences, School of Life and Health Sciences, University of Nicosia, 2417 Nicosia, Cyprus * Authors to whom correspondence should be addressed. † Presented at the 3rd International Electronic Conference on Biomolecules, 23–25 April 2024; Available online: https://sciforum.net/event/IECBM2024. Proceedings 2024, 103(1), 48; https://doi.org/10.3390/proceedings2024103048 Published: 12 April 2024 (This article belongs to the Proceedings of The 3rd International Electronic Conference on Biomolecules) Download keyboard_arrow_down Download PDF Download PDF with Cover Download XML Download Epub Versions Notes Keywords: dermo-cosmetics; synthetic peptides; acetyl hexapeptide-1; gene expression analysis; cosmeceuticals 1. IntroductionDermo-cosmetics are cosmetics combined with bioactive ingredients to impart therapeutic benefits on the skin and have made significant advances in recent decades. Synthetic peptides stand out among these bioactive molecules, exhibiting improved capabilities due to their synthetic nature. Wound healing and cosmetic peptides share similarities in tissue repair and regeneration. Cosmetic peptides enhance fibroblasts, boosting collagen formation, improving skin firmness, and aiding in wrinkle removal. E-cadherin, a key molecule, plays a role in both wound healing and cellular processes. Genetic validation of cosmetic peptides' effects is often lacking despite clinical trials examining their impact on skin physiology. This study examines acetyl hexapeptide-1's genetic impact on wound healing and its anti-aging properties. 2. MethodsAcetyl hexapeptide-1 was synthesized in-house, and human hepatocytes (HepG2) were subjected to cytotoxicity assessment. Furthermore, gene expression was evaluated, through qPCR analysis, for the apoptosis-related gene BAX and the wound healing-associated gene CDH-1. 3. ResultsIn the assessment conducted in cell cultures, the peptide demonstrated a notable absence of cytotoxic effects. Upon comprehensive gene expression analysis, noteworthy observations included a significant increase in E-cadherin expression from the first 24 h and a slight reduction in apoptotic BAX gene expression. 4. ConclusionsThe findings of this study provide promising insights into the molecular properties of synthetic acetyl hexapeptide-1, suggesting its potential in cosmeceuticals and dermo-cosmetics. While they have already proven effective in wrinkle reduction through fibroblast activation and collagen enhancement, these cosmetic peptides present vast potential and diverse applications beyond skincare. Further investigations are needed to fully comprehend their benefits and broaden their scope by exploring their molecular mechanisms across various applications. Author ContributionsConceptualization, A.N.M. and Y.S.; methodology, N.T., A.N.M. and Y.S.; software, A.N.M. and Y.S; validation, N.T., A.N.M. and Y.S.; formal analysis, A.N.M. and Y.S.; investigation, N.T., A.N.M. and Y.S.; resources, C.P. and Y.S.; writing—original draft preparation, N.T., A.N.M. and Y.S.; writing—review and editing, C.P., A.N.M. and Y.S; supervision, A.N.M. and Y.S.; project administration, A.N.M. and Y.S.; funding acquisition, C.P. and Y.S. All authors have read and agreed to the published version of the manuscript.FundingThis research received no external funding.Institutional Review Board StatementNot applicable.Informed Consent StatementNot applicable.Data Availability StatementThe data that support the findings of this study are available on request from the corresponding author A.N.M.Conflicts of InterestThe authors declare no conflict of interest.Disclaimer/Publisher's Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Share and Cite MDPI and ACS Style Topouzidou, N.; Petrou, C.; Miliotou, A.N.; Sarigiannis, Y. Genetic Insights into E-Cadherin Modulation: Exploring the Benefits of Synthetic Acetyl Hexapeptide-1 in Wound Healing and Anti-Aging for Dermo-Cosmetics. Proceedings 2024, 103, 48. https://doi.org/10.3390/proceedings2024103048 AMA Style Topouzidou N, Petrou C, Miliotou AN, Sarigiannis Y. Genetic Insights into E-Cadherin Modulation: Exploring the Benefits of Synthetic Acetyl Hexapeptide-1 in Wound Healing and Anti-Aging for Dermo-Cosmetics. Proceedings. 2024; 103(1):48. https://doi.org/10.3390/proceedings2024103048 Chicago/Turabian Style Topouzidou, Nikoleta, Christos Petrou, Androulla N. Miliotou, and Yiannis Sarigiannis. 2024. "Genetic Insights into E-Cadherin Modulation: Exploring the Benefits of Synthetic Acetyl Hexapeptide-1 in Wound Healing and Anti-Aging for Dermo-Cosmetics" Proceedings 103, no. 1: 48. https://doi.org/10.3390/proceedings2024103048 Article Metrics No No Article Access Statistics Multiple requests from the same IP address are counted as one view.