Enhanced Bone Healing Through Systemic Capsaicin Administration: An Experimental Study on Wistar Rats

Background:The healing of bone defects is a serious challenge worldwide.One branch of dentistry deals with bone defects.Capsaicin has anti-inflammatory, anti-oxidative, and cholesterol-reducing effects.The aim of this study was to evaluate the effects of systemic capsaicin administered at different doses on bone healing. Material/Methods:A total of 32 male wistar rats was used, their weight varying between 250 and 300 g.The rats were randomly divided into 4 groups of 8 rats each.The analyses served to evaluate the effect on healing of different doses of capsaicin and grafts.A significant increase was observed in the number of osteoblasts in the capsaicinapplied groups, compared with the control group. Results:The analyses served to evaluate the effect on healing of different doses of capsaicin and grafts.A significant increase was observed in the number of osteoblasts in the capsaicin-applied groups, compared with that of the control group.The inflammation scores showed a significant difference only in the control group and in the group administered with 50 mg/kg capsaicin (P=0.010).The osteoclast counts were significantly different between all groups. Conclusions:As a result of the analyses, positive effects on bone healing were observed when capsaicin 0.25 mg/kg and 0.50 mg/kg was administered intraperitoneally.However, more studies are needed for more accurate information.