RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses

Emil K. Gustavsson; Jordan Follett; Joanne Trinh; Sandeep Kumar Barodia; Raquel Real; Zhiyong Liu; Melissa Grant‐Peters; Jesse D. Fox; Silke Appel‐Cresswell; A. Jon Stoessl; Alex Rajput; Ali H. Rajput; Roland Auer; Russel Tilney; Marc Sturm; Tobias B. Haack; Suzanne Lesage; Christelle Tesson; Alexis Brice; Carles Vilariño‐Güell; Mina Ryten; Matthew S. Goldberg; Andrew B. West; Joshua Shulman; Huw R. Morris; Manu Sharma; Ziv Gan‐Or; Bedia Samancı; Paweł Lis; María Teresa Periñán; Rim Amouri; Samia Ben Sassi; F. Hentati; Francesca Tonelli; Dario R. Alessi; Matthew J. Farrer

doi:10.1016/s1474-4422(24)00121-2

Abstract

Parkinson's disease is a progressive neurodegenerative disorder with multifactorial causes, among which genetic risk factors play a part. The RAB GTPases are regulators and substrates of LRRK2, and variants in the LRRK2 gene are important risk factors for Parkinson's disease. We aimed to explore genetic variability in RAB GTPases within cases of familial Parkinson's disease.

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Gustavsson et al. (2024) studied this question.

synapsesocial.com/papers/68e6f976b6db64358767412c https://doi.org/10.1016/s1474-4422(24)00121-2

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RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses

Abstract

Discussion

Cite This Study

RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses

Abstract

Discussion

Cite This Study

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