Molecular profiling of primary endometrioid endometrial cancer and matched lung metastases: CTNNB1 mutation as a potential driver

• Both primary endometrial cancers (ECs) and matched lung metastases shared a common ancestor with independent evolution at each site. • The two endometrioid ECs studied acquired additional mutations during the distant metastatic process. • Subclonal CTNNB1 hotspot mutations in the two primary ECs studied became clonal in the distant metastases.