Chemical synthesis study demonstrates total synthesis of aspidosperma alkaloid cores using a photoredox cascade, highlighting streamlined access to aspidospermidine and limaspermidine.
A novel strategy for the synthesis of Aspidosperma alkaloids has been achieved via a photoredox-initiated [2+2]/retro-Mannich reaction of tryptamine-substituted enaminones as a key step. The developed chemistry has been applied to the construction of the core tetracycle of Aspidosperma alkaloids (±)-aspidospermidine and (±)-limaspermidine.
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Long et al. (2024) studied this question.
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