Shows that nerve growth factor enhances connexin-43 expression in pulmonary arterial smooth muscle, indicating a key mechanism that drives pulmonary artery hyperreactivity.
Pulmonary hypertension (PH) is characterised by an increase in pulmonary arterial pressure, ultimately leading to right ventricular failure and death. We have previously shown that nerve growth factor (NGF) plays a critical role in PH. Our objectives here were to determine whether NGF controls Connexin-43 (Cx43) expression and function in the pulmonary arterial smooth muscle, and whether this mechanism contributes to NGF-induced pulmonary artery hyperreactivity.
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Cardouat et al. (2024) studied this question.
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