Preclinical and clinical evaluation demonstrates retinal synaptic injury predicts disease progression in multiple sclerosis, highlighting potential serum biomarkers.
To analyze retinal signs of synaptic injury in an animal model of inflammatory demyelination and neurodegeneration, i.e., EAE; to evaluate quantified assessment of a retinal layer with major synaptic component for predicting relentlessly progressive disability in MS; and to use a proteome-wide analysis of a deeply characterized MS population to explore the possibility of developing a serum-based biomarker that can quantify global synaptic injury.
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Cordano et al. (2024) studied this question.
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