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April 9, 2024Neurology

Imaging Outcomes of a Dopaminergic Neuronal Cell Therapy for Parkinson’s Disease: 18-month Results from a Phase 1 Study of Bemdaneprocel (S30.005)

Claire Henchcliffe Yilong Ma Harini Sarva Andrés M. Lozano Alfonso Fasano Suneil K. Kalia Kenny Yu Cameron Brennan Nicki Jennings Whitney stemple N Abid Marcus Yountz Ahmed Enayetallah Antoine Lampron Viviane Tabar David Eidelberg

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Abstract

Evaluate [18F]-fluorodopa (18F-DOPA) positron emission tomography (PET) signal 18 months post transplantation (6 months after cessation of immunosuppression) in 12 participants who received intraputamenal transplants of bemdaneprocel.

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Henchcliffe et al. (2024) studied this question.

synapsesocial.com/papers/68e6fdb8b6db643587678379 https://doi.org/10.1212/wnl.0000000000205067

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Continued Evaluation of Safety, Tolerability, and Clinical Outcomes in Participants with Parkinson’s Disease Throughout Three Years After Bemdaneprocel Administration (S26.003)Human Clinical Trial · 2026
2Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s diseaseOriginal Research · 2020 · 15 citations
3Human embryonic stem cell-derived dopaminergic cells for Parkinson's Disease: a phase I/II open-label trialEarly-Phase Clinical Trial · 2026
4Human embryonic stem cell-derived dopaminergic cells for Parkinson’s disease: a phase 1/2 open-label trialEarly-Phase Clinical Trial · 2026 · 6 citations
5Parkinson’s disease patients treated with fetal tissue are assessed three years after surgery. The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s diseaseHuman Clinical Trial · 2026

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Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model of Parkinson’s Disease2024
Incidental Detection of Meningioma in Suspected Parkinsonism Patients - A Case Series on <sup>18</sup> F-DOPA PET/MRI2026
Evaluation of the neurotrophic peptide mixture in pathogenetic therapy of patients with Parkinson’s disease2026

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