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April 9, 2024Neurology

A Case of Adult-onset MELAS as a Rapidly Progressive Dementia: Variant of Unknown Significance and the Importance of Neuropathologic Confirmation (P4-9.010)

Molly K. Wiggins Nikita Jain Jessica Tate Amelia Kirby Dennis W. Dickson James R. Bateman

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Abstract

To highlight the importance of adult-onset mitochondrial disorders in the differential diagnosis of rapidly progressive dementias. We present a case of mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) that was diagnosed at autopsy.

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Wiggins et al. (2024) studied this question.

synapsesocial.com/papers/68e6feb4b6db643587678b28 https://doi.org/10.1212/wnl.0000000000206273

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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