Distribution characteristics of Lipoprotein (a) and non-genetic factors in Chinese Han population

Objective : To explore the distribution characteristics and influencing factors of Lipoprotein (a) [Lp(a)] in Chinese Han population. Methods: In total, 2135 Chinese Han individuals who received physical examinations and lab tests from June 2019 to January 2020 in Health Management Institute, Chinese PLA General Hospital were enrolled in the current study. Basic clinical characteristics including disease history, family history, diet habit, blood lipid were collected. Results: A total of 1459 males and 676 females were finally enrolled to this research, with an average age of 48.09±7.98 years old and an overall level of LP (a) of 12.46±17.58 mg/dl. LP(a) increased gradually in 20-60 years. Women presented with a higher LP(a) than that of men in all age groups. The multivariate logistic regression revealed that the influencing factors of LP(a) varied with different cut-off points. Hypertension acted as the risk factor (P < 0.05), while fish consumption acted as the protective factor for the increase of LP (a) (P = 0.001) when the cut-off point was 30mg/dl. However, women and hypertension acted as the risk factors for the increase of LP (a) (P< 0.05) when the cut-off point was 50mg/dl. Conclusion: This research analyzed the clinical characteristics of Chinese Han population and investigated the potential influencing factors. Fish consumption is conducive to the decrease of LP(a). However, women and patients with hypertension should put more emphasis on the monitor of LP(a) and be wary of cardiovascular disease. This study may provide some evidence on the lifestyle management of Chinese Han population.