This study investigated the role of ceRNA networks in coronary atherosclerosis, focusing on genes co-expression with immune cells. Data from the GEO database was used for GO/KEGG analysis of DE-mRNA, and ceRNA networks were constructed via Cytoscape using predicted lncRNA-miRNA-mRNA regulatory pairs. The CIBERSORT algorithm assessed immune cell proportions, revealing significant correlations between specific immune cells and hub mRNAs in the ceRNA network, particularly involving ESR1. The findings offer new insights into the molecular mechanisms of atherosclerosis and potential diagnostic and therapeutic targets.
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Chen et al. (2024) studied this question.
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