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April 6, 2024Journal of the Endocrine SocietyOpen Access

Long-term Pegvisomant Therapy of Acromegaly: Effects on Bone Density, Turnover and Microstructure Using HRpQCT

Adriana P Kuker Sanchita Agarwal Elizabeth Shane Juliana Maciel Bicca Eliza B. Geer Serge Cremers Elzbieta Dworakowski Adi Cohen Thomas L. Nickolas Emily M. Stein Pamela U. Freda

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Abstract

Fracture rate is increased in patients with active acromegaly and those in remission. Abnormalities of bone microstructure are present in patients with active disease and persist despite biochemical control after surgery. Effects of treatment with the GH receptor antagonist pegvisomant on bone microstructure were unknown.

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Kuker et al. (2024) studied this question.

synapsesocial.com/papers/68e70200b6db64358767c679 https://doi.org/10.1210/jendso/bvae079

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