Target Analysis and Suspect Screening of Per- and Polyfluoroalkyl Substances in Maternal–Newborn Paired Samples near Fluorochemical Facilities

first_page Download PDF settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Target Analysis and Suspect Screening of Per- and Polyfluoroalkyl Substances in Maternal–Newborn Paired Samples near Fluorochemical Facilities † by Xinyi LuXinyi Lu SciProfiles Scilit Preprints.org Google Scholar and Jia BaoJia Bao SciProfiles Scilit Preprints.org Google Scholar * School of Environmental and Chemical Engineering, Shenyang University of Technology, Shenyang 110870, China * Author to whom correspondence should be addressed. † Presented at the 1st International Electronic Conference on Toxics, 20–22 March 2024; Available online: https://sciforum.net/event/IECTO2024. Proceedings 2024, 102(1), 21; https://doi.org/10.3390/proceedings2024102021 Published: 3 April 2024 Download keyboard_arrow_down Download PDF Download PDF with Cover Download XML Download Epub Versions Notes Keywords: per- and perfluoroalkyl substances (PFASs); PFASs congeners; target analysis; suspect screening; placental transfer; health risk 1. Introduction: Fuxin Fluorochemical Industrial Park is one of the main concentrated fluorochemical facilities in northeastern China. Our previous studies revealed that perfluorooctanoic acid (PFOA) and perfluorobutane sulfonate (PFBS) were the dominant PFAS contaminants determined in environmental samples around local fluorochemical facilities, and the levels of those two PFASs generally showed an increasing temporal trend over time.2. Method: In this study, 50 paired samples of maternal and cord serum as well as placenta were derived from Fuxin pregnant women. Twenty-one legacy PFASs were analyzed in all the samples via high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS), and novel PFASs in all the samples were beneficial for the method of suspect screening.3. Results: A total of 11 categories (49 species) of novel PFASs were identified in all samples, of which 4 categories (20 species) were discovered in human serum and placenta for the first time, accounting for 90% of maternal serum and 96% of placenta and umbilical cord serum. Legacy PFASs had median values of 1.2, 1.3, and 1.6 for mother–placenta transfer (Rm/p), placenta–newborn transfer (Rp/n), and mother–newborn transfer (Rm/n), respectively. Rm/p, Rp/n, and Rm/n for each novel PFAS were also able to be derived, with median values of 0.9, 1.2, and 0.8, respectively.4. Conclusions: In summary, of the 11 classes (49 species) of novel PFASs detected, 4 classes (20 species) had never been reported previously in human blood and placenta samples. Different from legacy PFCAs and PFSAs, most of the novel PFASs observed in placentas and cord sera had higher levels than those in maternal sera. Author ContributionsConceptualization, J.B.; methodology, J.B.; software, X.L.; validation, J.B.; formal analysis, X.L.; investigation, X.L.; resources, J.B.; data curation, X.L.; writing—original draft preparation, X.L.; writing—review and editing, J.B.; visualization, X.L.; supervision, J.B.; project administration, J.B.; funding acquisition, J.B. All authors have read and agreed to the published version of the manuscript.FundingThis research was funded by the National Natural Science Foundation of China (No. 21976124 and No. 21507092) and Applied Basic Research Plan of Liaoning Province (No. 2023JH2/101300059).Institutional Review Board StatementThe study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board of Shenyang University of Technology (2019-001 and 2019.03.06) for studies involving humans.Informed Consent StatementNot applicable.Data Availability StatementData are contained within the article.Conflicts of InterestThe authors declare no conflict of interest.Disclaimer/Publisher's Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Share and Cite MDPI and ACS Style Lu, X.; Bao, J. Target Analysis and Suspect Screening of Per- and Polyfluoroalkyl Substances in Maternal–Newborn Paired Samples near Fluorochemical Facilities. Proceedings 2024, 102, 21. https://doi.org/10.3390/proceedings2024102021 AMA Style Lu X, Bao J. Target Analysis and Suspect Screening of Per- and Polyfluoroalkyl Substances in Maternal–Newborn Paired Samples near Fluorochemical Facilities. Proceedings. 2024; 102(1):21. https://doi.org/10.3390/proceedings2024102021 Chicago/Turabian Style Lu, Xinyi, and Jia Bao. 2024. "Target Analysis and Suspect Screening of Per- and Polyfluoroalkyl Substances in Maternal–Newborn Paired Samples near Fluorochemical Facilities" Proceedings 102, no. 1: 21. https://doi.org/10.3390/proceedings2024102021 Article Metrics No No Article Access Statistics Multiple requests from the same IP address are counted as one view.