April 2, 2024

Neoadjuvant Chemotherapy With Oxaliplatin and Fluoropyrimidine Versus Upfront Surgery for Locally Advanced Colon Cancer: The Randomized, Phase III OPTICAL Trial

HHHuabin HuSun Yat-sen University JZJianwei ZhangHenan University YLYunfeng LiBeijing Institute of Petrochemical Technology

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Abstract

The role of neoadjuvant chemotherapy (NAC) in colon cancer remains unclear. This trial investigated whether 3 months of modified infusional fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or capecitabine and oxaliplatin (CAPOX) as NAC could improve outcomes in patients with locally advanced colon cancer versus upfront surgery.

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Hu et al. (Tue,) studied this question.

synapsesocial.com/papers/68e70a0bb6db643587684189 https://doi.org/https://doi.org/10.1200/jco.23.01889

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