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April 2, 2024Open Access

Supplementary Figure S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth

Kyle Begovich Angela Schoolmeesters Navin Rajapakse Elena Martínez‐Terroba Maneesh Kumar Arvind Shakya Chon Lai Steven Greene Brandon Whitefield Akinori Okano Venkat Mali Shenlin Huang Aparajita H. Chourasia Leah Fung

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Abstract

Supplementary Figure S2 shows the degradation-driven antiproliferative activity of BTX-6654 and BTX-7312 in K562 cells

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Cite This Study

Begovich et al. (2024) studied this question.

synapsesocial.com/papers/68e70c4bb6db643587685e70 https://doi.org/10.1158/1535-7163.25523405

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth2024
2Supplementary Figure S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth2024
3Supplementary Figure S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth2024
4Supplementary Figure S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth2024
5Supplementary Figure S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth2024

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Supplementary Figure S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth2024
Supplementary Figure S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth2024
Supplementary Methods from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth2024