ABSTRACT Autoimmune diseases arise from a breakdown in immune tolerance. This leads to self‐reactive immune responses and chronic inflammation. Induction of antigen‐specific tolerance offers a targeted approach that restores immune balance without global immunosuppression. We discuss current approaches to therapies that seek to induce tolerance. These include peptide‐, immunoglobulin‐, carrier‐, and cell‐based approaches. We review clinical trials and preclinical studies that explore novel strategies for the induction of durable (antigen‐specific) tolerance as possible interventions in autoimmune disease.
Faas et al. (2025) studied this question.