Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation

Marlies Boeren; Nicky de Vrij; My Kieu Ha; Sebastiaan Valkiers; Aisha Souquette; Sofie Gielis; Maria Kuznetsova; Jolien Schippers; Esther Bartholomeus; Johan van den Bergh; Nele Michels; Olivier Aerts; Julie Leysen; An Bervoets; Julien Lambert; Elke Leuridan; Johan Wens; Karin Peeters; Marie‐Paule Emonds; George Elias; Niels Vandamme; Hilde Jansens; Wim Adriaensen; Arvid Suls; Stijn Vanhee; Niel Hens; Evelien Smits; Pierre Van Damme; Paul G. Thomas; Philippe Beutels; Peter Ponsaerts; Viggo Van Tendeloo; Peter Delputte; Kris Laukens; Pieter Meysman; Benson Ogunjimi

doi:10.1016/j.celrep.2024.114062

Abstract

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The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts of herpes zoster (HZ) patients and controls to investigate whether TCR diversity against varicella-zoster virus (VZV) influences the risk of HZ. We show that CD4

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Boeren et al. (2024) studied this question.

synapsesocial.com/papers/68e70ef4b6db6435876882ff https://doi.org/10.1016/j.celrep.2024.114062

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Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation

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Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation

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