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April 1, 2024Translational Gastroenterology and HepatologyOpen Access

Family history as a major prerequisite for microsatellite instability screening in colorectal cancer is a poor selection tool

Daniel Jakob Valerie Orth Daniel Gödde Hubert Zirngibl Peter C. Ambe

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Abstract

Deficient mismatch repair (MMR) leading to microsatellite instability (MSI) in tumors is thought to be present in over 15% of colorectal cancer (CRC) cases. Testing CRC for MSI has traditionally been recommended following the fulfillment of clinical criteria. However, the performance of clinical criteria, especially the family history, as a selection tool for MSI screening in CRC is questionable.

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Jakob et al. (2024) studied this question.

synapsesocial.com/papers/68e71176b6db64358768a659 https://doi.org/10.21037/tgh-23-71

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